Heme arginate

Heme arginate
Identifiers
CAS number 100438-92-4
PubChem 3086464
MeSH Heme+arginate
Properties
Molecular formula C40H48FeN8O6+2
Molar mass 792.704
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Heme arginate (or haem arginate) is a compound of heme and arginine used in the treatment of acute porphyrias.[1][2] This heme product is only available outside the United States, where the equivalent is hematin.[3]

Heme arginate is a heme compound, whereby L-arginine is added to prevent rapid degradation. It is given intravenously, and its action of mechanism is to reduce the overproduction of δ-aminolevulinic acid, which can cause the acute symptoms in an attack of the acute porphyrias. [4]

See also

References

  1. ^ "HAEM ARGINATE FOR THE ACUTE ATTACK OF PORPHYRIA". Porphyria South Africa. http://www.porphyria.uct.ac.za/professional/prof-haem-therapy.htm. 
  2. ^ "Treatment of the Acute Attack". Eurpean Porphyria Network. http://www.porphyria-europe.org/02-for-healthcare/treatment.asp. Retrieved 28 August 2011. 
  3. ^ "Panhematin for Acute Porphyria". American Porphyria Foundation. http://www.porphyriafoundation.com/testing-and-treatment/medications-for-porphyria/panhematin. Retrieved 28 August 2011. 
  4. ^ Volin, L; V Rasi, E Vahtera and R Tenhunen (1988). "Heme arginate: effects on hemostasis". Blood Journal 71: 625–628. http://bloodjournal.hematologylibrary.org/content/71/3/625.full.pdf. Retrieved 28 August 2011.